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Review
Circulating Tumor DNA in Primary and Secondary Liver Cancers: A Comprehensive Review
Hanna Hong1,†, Chase J Wehrle1,*,†, Omer Faruk Karakaya1, Noah Tocci1, Pranav Kumar1, Keyue Sun2, Chunbao Jiao2, Sangeeta Satish1, Rebecca Panconesi1, Jamak Modaresi Esfeh3, Maureen Whitsett Linganna3, Koji Hashimoto1, Andrea Schlegel1,2, Charles Miller1, David C.H. Kwon1, Federico Aucejo1
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Affiliation
1
Department of Hepato-Pancreato-Biliary & Liver Transplant Surgery, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
2
Department of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
3
Department of Gastroenterology, Cleveland Clinic Foundation, Digestive Diseases and Surgery Institute, Hepatology, and Nutrition, Cleveland, OH 44195, USA
*Correspondence:
wehrlec@ccf.org (Chase J Wehrle)
†These authors contributed equally.
†These authors contributed equally.
Front. Biosci. (Schol Ed) 2025, 17(2),
26972;
https://doi.org/10.31083/FBS26972
Submitted:
15 October 2024 |
Revised:
6 January 2025 |
Accepted:
10 January 2025 |
Published:
18 June 2025
Copyright: © 2025 The Author(s). Published by IMR Press.
This is an open access article under the
CC BY 4.0 license.
Abstract
Similar to many other cancer types, liver malignancies pose the common challenges of late detection of primary tumors and recurrences. Liquid biopsies, which assess the presence of circulating tumor DNA, have emerged as a novel, non-invasive clinical tool for diagnostic and surveillance purposes. This review represents an introductory and comprehensive overview of the current circulating tumor DNA (ctDNA) literature relevant to primary and secondary liver malignancies. Herein, we highlight key findings, landmark discoveries, challenges, and future directions.
Keywords
circulating tumor DNA
ctDNA
liquid biopsy
liver cancer
liver malignancy
Figures
Fig. 1.