IMR Press / FBS / Volume 14 / Issue 2 / DOI: 10.31083/j.fbs1402009
Open Access Original Research
Taxonomic position, antibiotic resistance and virulence factors of clinical Achromobacter isolates
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1 Department of Medical Microbiology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
2 Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain
3 Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, 28029 Madrid, Spain
4 School of Pharmacy, Queen’s University Belfast, BT9 7BL Belfast, UK
5 Department of Medical Microbiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
6 Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), 6532 SZ Nijmegen, The Netherlands
7 Centre of Expertise in Mycology Radboudumc/Canisius-Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands
8 Department of Medical Microbiology, Radboudumc, 6500 HB Nijmegen, The Netherlands
9 School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, BT9 7BL Belfast, UK
*Correspondence: a.c.fluit@umcutrecht.nl (Ad C. Fluit)
Academic Editor: Gustavo Caetano-Anollés
Front. Biosci. (Schol Ed) 2022, 14(2), 009; https://doi.org/10.31083/j.fbs1402009
Submitted: 17 December 2021 | Revised: 9 February 2022 | Accepted: 11 February 2022 | Published: 21 March 2022
(This article belongs to the Special Issue Cystic fibrosis)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

The role of Achromobacter species in lung disease remains unclear. The aim of this study was to characterize Achromobacter isolated from persons with cystic fibrosis and from other clinical samples. Whole genome sequences from 101 Achromobacter isolates were determined (81 from patients with cystic fibrosis and 20 from other patients) and analysed. Taxonomic analysis showed nine species including two putative novel species. Thirty-five novel sequence types were present. The most active agent was co-trimoxazole followed by imipenem, but Minimal Inhibitory Concentrations (MICs) were high. Acquired antibiotic resistance genes were rare. Their presence did not correlate with minimal inhibitory concentrations suggesting that other mechanisms are involved. Genes for proposed virulence factors were present in only some isolates. Two putative novel species were identified. The putative virulence properties of Achromobacter involved in infections are variable. Despite the high MICs, acquired resistance genes are uncommon.

Keywords
Achromobacter
cystic fibrosis
antibiotic resistance
virulence
taxonomy
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