IMR Press / FBS / Volume 13 / Issue 2 / DOI: 10.52586/S558
Open Access Review
Repertoires of MicroRNA-30 family as gate-keepers in lung cancer
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1 Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore, 575018 Karnataka, India
2 Department of Pulmonary Medicine, K S Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangaluru, 575018 Karnataka, India
3 Department of Pulmonary Medicine, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore, 575018 Karnataka, India
Front. Biosci. (Schol Ed) 2021, 13(2), 141–156; https://doi.org/10.52586/S558
Submitted: 9 December 2021 | Revised: 4 February 2021 | Accepted: 2 March 2021 | Published: 3 December 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract

Lung cancer is a prominent global health issue responsible for the highest fraction of cancer-related mortality. The disease burden has incited the investigation of associated molecular pathways, to explore better therapeutic possibilities. MicroRNAs are extensively studied in recent years for their pivotal role in the regulation of several tumorigenic pathways. MicroRNA-30 (miR-30) family is primarily investigated in case of non-small cell lung cancer (NSCLC) and has been found to play the role of a tumour suppressor. There are six members of miR-30 family: miR-30a, miR-30b, miR-30c-1, miR-30c-2, miR-30d and miR-30e. They regulate several imperative signalling pathways like p53, PI3K/AKT, resulting in the modulation of key carcinogenic events involving cell proliferation, apoptosis, metastasis, epithelial-mesenchymal transition, and drug resistance. Their altered levels are documented in NSCLC tissue and blood samples. They are suggested as biomarkers of disease progression and therapeutic outcomes in lung cancer. They possess immense therapeutic potential in the treatment of lung cancer and combat the emerging problem of drug resistance by modulating prime regulatory axes. However, there are many limitations in the existing studies, and additional research is required for the comprehensive understanding of pathways so that the tumour suppressive potential of miR-30 can be translated into clinical benefits. In this review, we present a deeper understanding of the regulatory role and clinical significance of miR-30 and have emphasized the emerging roles in lung cancer.

Keywords
Lung cancer
miR-30 family
Biomarker
Therapeutic potential
Signalling pathway
Tumour-suppressor
Figures
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