IMR Press / FBS / Volume 1 / Issue 2 / DOI: 10.2741/S39

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Integrins and extracellular matrices in pancreatic tissue engineering

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1 Childrens' Health Research Institute, University of Western Ontario, London, ON, Canada
2 Department of Pathology, University of Western Ontario, London, ON, Canada
3 Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
4 Medicine, University of Western Ontario, London, ON, Canada

*Author to whom correspondence should be addressed.

Academic Editors: Patrick Vermette, Jonathan Lakey, Rennian Wang, Steven Paraskevas

Front. Biosci. (Schol Ed) 2009, 1(2), 477–491;
Published: 1 June 2009

The role of integrin receptors in regulating numerous cellular programs have been well studied in the endocrine pancreas. These adhesion receptors and their interactions with the extracellular matrix (ECM) are important determinants of islet cell biology as they influence the development, survival and function of the islets of Langerhans. In this review, we will discuss the profound role of integrin-ECM relationships in controlling pancreatic tissue morphogenesis and the anti-apoptotic properties that these receptors confer through their dynamic and unique signaling pathways. Relationships between the ECM-integrin receptors will also be discussed in light of islet-based therapies including transplantation procedures and pancreatic tissue engineering initiatives.

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