IMR Press / FBS / Volume 1 / Issue 2 / DOI: 10.2741/S34

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Fabrication of biological arrays by unconventional lithographic methods
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1 Department of Mechanical Engineering, Inha University, 253 Young Hyun-dong, Nam-gu, Incheon, 402-751, Republic of Korea
2 School of Mechanical and Aerospace engineering and the Institute of Advanced Machinery and Design, Seoul National University, San 56-1, Shinlim-dong, Kwanak-gu, Seoul, 151-742, Republic of Korea

*Author to whom correspondence should be addressed.

Academic Editor: Zhang Guojun

Front. Biosci. (Schol Ed) 2009, 1(2), 406–419;
Published: 1 June 2009
(This article belongs to the Special Issue Nanostructures for biological and medical applications)

Biological arrays with dimensions less than 100 nm are emerging as a new tool for biological research in the fields of genomics, proteomics, cell analysis, and tissue engineering. In this review, unconventional lithographic methods for the fabrication of biological arrays are summarized and compared in terms of spot size, density, resolution and ease in fabrication. The methods are classified into three categories: a) direct transfer of biological species on the substrate, b) selective deposition on the patterned surface using an adhesion-controlled template material, and c) stencil or membrane-based deposition on specific regions of a substrate. This review would be useful to related researchers in bioscience and bioengineering.

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