IMR Press / FBL / Special Issues / modulation_oxidative_stress

Modulation of Oxidative Stress: Molecular and Pharmacological Aspects

Submission deadline: 15 November 2022
Special Issue Editors
  • Luciano Saso, PhD
    Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy
    Interests: pharmacology; modulation of oxidative stress
  • Grzegorz Wegrzyn, PhD
    Department of Molecular Biology, University of Gdansk, Gdansk, Poland
    Interests: regulation of DNA replication; control of gene expression; oxidative stress in bacterial virulence; molecular mechanisms of mucopolysaccharidoses; development of novel therapeutic options
  • Hande Gurer-Orhan, PhD
    Toxicology Department, Faculty of Pharmacy, Ege University, Izmir, Turkey
    Interests: screening novel natural and synthetic endocrine modulating compounds; assessment of their potential safety and efficiency for treatment of hormone-related cancers; investigating efficiency and toxicity of novel synthetic oxidative stress modulators
Special Issue Information

Dear Colleagues,

Oxidative stress is defined as an imbalance between the generation of highly reactive oxygen species and their detoxification by the defense system of the organism. Over the past three decades, reactive oxygen species have been implicated in the pathogenesis of various diseases such as diabetes, neurodegenerative diseases and cancer, as well as the physiological process of aging. Therefore, antioxidant supplementation and boosting the antioxidant defenses of the body have been proposed in order to prevent the deleterious effects of excess reactive oxygen species. High concentrations of reactive oxygen species activate the cell death signaling pathways of apoptosis and necroptosis, while low concentrations are thought to exert beneficial effects by activating cell survival signaling pathways such as UPR, and Nrf2. The latter pathways are essential for redox homeostasis and proper functioning of the cardiovascular and immune systems. Nrf2 is a transcription factor that regulates cellular defense against oxidative damage through the expression of genes involved in the oxidative stress response. Nrf2 activation provides cells with resistance against neoplastic transformation and inflammatory challenges. 

When considering the molecular genetic aspects of oxidative stress, it is important to note that DNA damage induced by reactive oxygen species increases the rate of mutations and causes various abnormalities in cells. Modulation of gene expression leads to changes in the levels of functional nucleic acids (i.e. regulatory RNAs) and proteins. Subsequently, the disruption of protein structures leads to their malfunction, causing alterations to metabolic pathways and cellular processes.

Potential topics for this Special Issue include, but are not limited to:

•    Advances in redox-active prodrugs in cancer
•    Natural or synthetic small molecules as ROS-targeted anticancer therapeutics
•    Non-radical scavenging mechanisms targeting oxidative stress in cancer
•    Nrf2/Keap1 pathway-targeted therapeutics in cancer
•    Preclinical designing and development of small molecules targeting redox regulation for their cancer therapeutic potentials 
•    Biomarkers for assessing redox imbalance and antioxidant status
•    Molecular mechanisms of oxidative stress regulation
•    Genetic consequences of oxidative stress
•    Involvement of ROS and oxidative stress in neurodegenerative diseases
•    Activities of antioxidants as potential therapeutic agents in the treatment of genetic and neurodegenerative diseases

Prof. Luciano Saso, Prof. Grzegorz Wegrzyn and Prof. Hande Gurer-Orhan

Guest Editors

modulators of oxidative stress
molecular mechanism
Nrf2/Keap1 pathway
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

Published Paper (1 Paper)
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