Pathomechanism of Mucopolysaccharidosis
Submission Deadline: 30 Jun 2025
Guest Editor
Department of Molecular Biology, University of Gdansk, Gdansk, Poland
Interests: Genetic and neurodegenerative diseases; lysosomal storage diseases; molecular mechanisms of inherited metabolic diseases; regulation of gene expression; DNA replication control
Special Issue in IMR Press journals
Special Issue Information
Dear Colleagues,
Mucopolysaccharidoses (MPS) refers to a group of lysosomal storage disorders. These are severe, monogenic, inherited metabolic diseases caused by mutations in genes coding for enzymes involved in the degradation of glycosaminoglycans (GAGs). Lysosomal storage of GAGs is the primary biochemical defect. However, recent studies suggest the underlying pathological mechanisms of MPS are much more complicated. Secondary and tertiary effects can significantly modulate the disease course and may be as important as the primary cause. Furthermore, the development of effective therapies require detailed knowledge of the disease mechanism(s). This special issue will publish high quality articles on the pathological mechanisms of MPS. Both original research papers and review articles are welcome, provided they make a significant contribution to our understanding of the mechanisms of these diseases. Papers describing the development of potential new therapies for MPS are also welcome.
Grzegorz Węgrzyn
Guest Editor
Keywords
- Mucopolysaccharidoses
- lysosomal storage disease
- glycosaminoglycans
- inheritance
- pathomechanism
- gene expression regulation
- therapy for genetic disease
Manuscript Submission Information
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.
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