Dear Colleagues,
Despite discoveries in the field of redox signaling, oxidative stress is still commonly considered a harmful and uncontrolled process associated with the major diseases of modern mankind.
It is also assumed that the distinction between (patho)physiological and dangerous oxidative stress is based on the onset of lipid peroxidation (LPO), especially in the case of non-enzymatic chain reactions. Although these reactions usually occur in the case of free radical attack on polyunsaturated fatty acids, such LPO may generate reactive aldehydes, which are not reactive oxygen species (ROS), but may act as “second messengers of ROS.” Among these, due to its bioactivities and biomedical relevance, 4-hydroxynonenal (HNE) is considered to be the major LPO product. HNE has strong affinity to bind to proteins, thus changing their structure and function. Consequently HNE can regulate the bioactivities of proteins as well as various cellular processes in concentration- and cell-type dependent manners.
Therefore, similar to other pathophysiological processes including oxidative stress, LPO can be either acute or chronic, harmful causing irreversible damage to bioactive macromolecules, physiological in the case of metabolism and synthesis of signaling molecules, or even an essential component of inflammatory processes.
This Special Issue dedicated to LPO will tackle this complex topic with the aim of publishing original research and review papers exploring both positive as well as negative aspects of LPO.
Prof. Dr. Neven Zarkovic
Guest Editor
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2600 USD. Submitted manuscripts should be well formatted in good English.