IMR Press / FBL / Volume 9 / Issue 5 / DOI: 10.2741/1461

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Soluble interleukin-2 receptor in cancer
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1 Department of Surgery, Saitama Medical School, Morohongo 38, Moyorama-machi, Iruma-gunn,Saitama, 350-0495, Japan
Front. Biosci. (Landmark Ed) 2004, 9(5), 3085–3090; https://doi.org/10.2741/1461
Published: 1 September 2004
Abstract

Levels of serum sIL-2R (soluble interleukin-2 receptor) reflect the total amount of activated T lymphocytes in tumor infiltrating lymphocytes of cancer tissues and metastatic organs, because a part of α-chain of IL-2R is released into the bloodstream on the attachment of IL-2 (interleukin-2) to its specific IL-2R membrane. In most malignant diseases, elevated levels of serum sIL-2R are found, compare to normal control. Serum sIL-2R is a useful parameter for evaluating the disease stage and monitoring the disease progression during the post-treatment follow-up, though it is not an organ-specific parameter.

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