IMR Press / FBL / Volume 9 / Issue 3 / DOI: 10.2741/1378

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Expression of cytochrome P450 in tumor tissues and its association with cancer development
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1 Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
2 Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
3 Department of Health Information Science, School of Health Science, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
4 1st Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan
5 Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea
Academic Editor:Norio Kagawa
Front. Biosci. (Landmark Ed) 2004, 9(3), 1967–1976; https://doi.org/10.2741/1378
Published: 1 May 2004
(This article belongs to the Special Issue Gene regulation and structure-function of P450 Cold stress response)
Abstract

CYPs (cytochrome P450s) catalyze the conversion of numerous numbers of xenobiotics including carcinogens and drugs. CYPs can be involved in metabolic pathways of activation of procarcinogens and/or inactivation of carcinogens during the tumorigenic processes. Recently, increasing number of cancer tissues as well as normal tissues have been found to express a variety of CYPs. The local expression of CYPs in tumors appears to be very important for the management of cancers since CYPs expressed in tumors may be involved in activation and/or inactivation of anticancer drugs. The expression of CYPs in tumors may also convert endogenous substrates to metabolites that facilitate cancer development. In this review, we summarize the association of CYP expression in cancer tissues with carcinogenesis and cancer treatment.

Keywords
Cytochrome P450
Tumor
Extrahepatic expression
Drug metabolism
Carcinogenesis
Review
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