IMR Press / FBL / Volume 9 / Issue 2 / DOI: 10.2741/1333

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Main features on tailed phage, host recognition and DNA uptake
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1 Institut de Biochimie et Biophysique Moléculaire et Cellulaire, UMR CNRS 8619, Université Paris Sud, Bât 430; 91405 Orsay cedex, France
Academic Editor:Phillip Klebba
Front. Biosci. (Landmark Ed) 2004, 9(2), 1228–1339;
Published: 1 May 2004
(This article belongs to the Special Issue Bacterial membrane transport)

Phage nucleic acid transport is atypical among membrane transport and thus poses a fascinating problem: transport is unidirectional; it concerns a unique molecule the size of which may represent 50 times that of the bacterium. The rate of DNA transport can reach values as high as 3 to 4 thousands base pairs/sec. This raises many questions, which will be addressed in this review. Is there a single mechanism of transport for all types of phages? How does the phage genome overcome the hydrophobic barrier of the host envelope? Is DNA transported as a free molecule or in association with proteins? Is such transport dependent on phage and/or host cell components? What is the driving force for transport? Data will be presented for a few selected tailed phages, which are the most common type of phages and for which DNA transport has been most extensively studied. Part of the review is devoted to recent in vitro data which have allowed to partly decipher the mechanism of phage T5 DNA transport.

DNA transport
Escherichia coli
Outer Membrane Receptors
Cryo Electron Microscopy
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