IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1198

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cellular-resolution activity mapping of the brain using immediate-early gene expression
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1 Department of Psychology, McGill University, Montreal, Canada
Academic Editor:John Leah
Front. Biosci. (Landmark Ed) 2004, 9(1), 104–109; https://doi.org/10.2741/1198
Published: 1 January 2004
(This article belongs to the Special Issue Regulation of gene expression in the brain)
Abstract

Immediate-Early Genes are a class of genes that are rapidly up-regulated following neural stimulation. Due to their quality as potential activity markers in the CNS, they have been used extensively in functional mapping studies. At least three genes have been popularly used, including zif268 (Egr1, NGFI, Krox-24, or ZENK), c-fos and recently, Arc. A number of techniques have been developed in applying IEG labelling for the development of functional maps, thus overcoming some of the earlier limitations of this approach. Current developments highlight the future prospects of cellular-resolution functional activity mapping of the brain.

Keywords
Immediate-Early Genes
Molecular Mapping
Neural Activity
Egr-1
Zif268
Arc
gene expression
dual activity mapping. c-fos
IEG
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