IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1197

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
CREB and neurodegeneration
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1 Department of Pharmacology, University of Auckland, Auckland, New Zealand
Academic Editor:John Leah
Front. Biosci. (Landmark Ed) 2004, 9(1), 100–103; https://doi.org/10.2741/1197
Published: 1 January 2004
(This article belongs to the Special Issue Regulation of gene expression in the brain)
Abstract

Programmed cell death (PCD) is major concept in neurobiology and transcription factors are pivotal in switching on the nerve cell death program. More recently, the transcriptional control of programmed cell life (PCL) is beginning to be understood. This work began in studies of the activation of the CREB transcription factor in stroke models where it was shown that CREB is phosphorylated (and presumably activated) in neurons that survive this insult. In this review I will describe this data and also discuss the up-stream and down-stream pathways in this CREB neuroprotective transcriptional cassette. Finally, I will discuss studies showing that this CREB survival pathway may be inactivated by neurotoxins and genes involved in neurodegenerative disorders.

Keywords
Apoptosis
Programmed Cell Life
Neurogenesis
Review
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