IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1196

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The mammalian circadian clock: a network of gene expression
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1 Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Academic Editor:John Leah
Front. Biosci. (Landmark Ed) 2004, 9(1), 48–55;
Published: 1 January 2004
(This article belongs to the Special Issue Regulation of gene expression in the brain)

The circadian timing system provides a temporal structure across an organism to modulate and synchronize biological function. The mammalian circadian system is composed of many individual clocks. Circadian clocks are found in individual cells that have to be synchronized by a central pacemaker. This pacemaker can be viewed as a managing director who coordinates temporal physiology and behavior in the organism. In this review I will discuss the current understanding of the clock mechanism at the molecular level, how it adjusts to environmental changes and what the implications of a defect in the circadian clock are on mammalian physiology.

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