IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/981

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Aspergillus antigens associated with allergic bronchopulmonary aspergillosis
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1 Centre For Biochemical Technology, Delhi, India
2 Allergy-Immunology Division, Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, Research Service 151-I, V A Medical Center, 5000 West National Avenue, Milwaukee, WI 53295
Front. Biosci. (Landmark Ed) 2003, 8(6), 102–109;
Published: 1 January 2003

Among the molds causing allergy, Aspergillus fumigatus (Af) constituted a major species present both indoors and outdoors. The antigens both secreted and bound to hyphae and conidia have been isolated for immunodiagnosis of allergic aspergillosis. The crude extracts have been used to demonstrate IgE antibody in vitro and for skin testing. The crude extracts contain many antigenic and non-antigenic components and toxins and have demonstrated inconsistent reactivities. In addition, similarity with other allergens also may complicate specific diagnosis. A number of methods including conventional purification and fractionation methods have been used to obtain relevant antigens. In recent years, monoclonal antibody dependent affinity purification and molecular biology methods have obtained considerable progress in the allergen purification and in developing specific and reliable immunoassays. However, international standards are still lacking and hence, comparison of results among laboratories are not possible yet.

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