IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/980

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Functional implication of the interaction between EGF receptor and c-Src
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1 Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, ROC
2 Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan, R.O.C.

Academic Editor: Jie Wu

Front. Biosci. (Landmark Ed) 2003, 8(6), 28–38; https://doi.org/10.2741/980
Published: 1 January 2003
(This article belongs to the Special Issue Biology and medicine of ErbB tyrosine kinases)
Abstract

EGF receptor (EGFR) and c-Src are the prototypes that individually represent the receptor and nonreceptor tyrosine kinases respectively. Accumulated evidence reveals the association between EGF-activated EGFR and c-Src that leads to activation of both kinases. Importantly, their mutual interaction is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis. Interestingly, activation of c-Src and its association with transactivated EGFR is also observed in cells stimulated with non-EGF agonists. This review will not only discuss the structure, function and regulation of these two tyrosine kinases, but also will summarize our current knowledge of the molecular mechanisms depicting the cellular events that require their participation.

Keywords
EGF
Stat
Kinase
Tyrosine
EGFR
c-Src
GPCR
Review
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