IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/1011

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Specificity in signaling by c-Yes
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1 Dept. of Microbiology and Immunology and Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown WV 26506-9300, USA
2 Dept. of Biochemisry, The Mount Sinai School of Medicine. New York, NY
3 Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA
4 Strang Cancer Prevention Center and Weil Medical College of Cornell University, NY, NY

Academic Editor: Antonio Giordano

Front. Biosci. (Landmark Ed) 2003, 8(6), 185–205;
Published: 1 January 2003
(This article belongs to the Special Issue Gene targets for modulating cell growth)

c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases, there is also a growing body of evidence to indicate specificity in signaling. In this review, we summarize c-Yes, its potential functions and its ability to modulate signals that are distinct from c-Src.

Tyrosine Kinases
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