IMR Press / FBL / Volume 8 / Issue 5 / DOI: 10.2741/925

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Renal fibrosis
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1 Division of Pediatric Nephrology, Northwestern University, Medical School, Chicago, IL, USA

Academic Editor: Marcos Rojkind

Front. Biosci. (Landmark Ed) 2003, 8(5), 68–86; https://doi.org/10.2741/925
Published: 1 January 2003
(This article belongs to the Special Issue From regeneration to scar formation)
Abstract

Renal fibrosis causes significant morbidity and mortality as the primary acquired lesion leading to the need for dialysis or kidney transplantation. Fibrosis can occur in either the filtering or reabsorptive component of the nephron, the functional unit of the kidney. Experimental models have identified a number of factors that contribute to renal scarring, particularly derangements of physiology involved in the autoregulation of glomerular filtration. This in turn leads to replacement of normal structures with accumulated extracellular matrix (ECM). A spectrum of changes in the physiology of individual cells leads to the production of numerous peptide and non-peptide fibrogens that stimulate alterations in the balance between ECM synthesis and degradation to favor scarring. Other proteins and small molecules may have anti-fibrotic effects. Manipulation of these opposing systems holds the promise of effective treatments for chronic progressive kidney disease.

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