Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Lipoprotein lipase as a therapeutic target for dyslipidemia
Sivaram Pillarisetti 1,*
, Uday Saxena 1
, Uday Saxena 1Affiliation
Article Info
1 Reddy US Therapeutics, 3065 Northwoods Circle, Norcross, GA 30071, USA
Abstract
The importance of lipoprotein lipase (LPL) in the regulation of overall lipid metabolism in humans and other animals is well documented. The major goal of this review is to identify and justify features that make LPL an important drug target for lipid management in particular for triglyceride lowering and HDL elevation, and propose strategies to modulate LPL activity.