IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A835

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Ion conduction and selectivity in the ryanodine receptor channel
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1 Cardiac Medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College of Science, Technology & Medicine, Dovehouse St., London SW3 6LY, United Kingdom
Academic Editor:Hector Valdivia
Front. Biosci. (Landmark Ed) 2002, 7(4), 1223–1230; https://doi.org/10.2741/A835
Published: 1 May 2002
(This article belongs to the Special Issue The structure and function of calcium release channels)
Abstract

The ryanodine receptor channel is an intracellular membrane Ca2+-release channel. The investigation of ion translocation and discrimination in individual channels under voltage-clamp conditions has revealed that the channel can sustain very high rates of cation translocation, has high affinity for divalent cations and displays relatively poor discrimination between physiologically relevant cations. In this article I will discuss the mechanisms underlying these characteristic properties, the regions of the channel molecule likely to be involved in ion handling and speculate on the structure of the conduction pathway of Ca2+-release channels.

Keywords
Ca2+-release channel
ryanodine receptor
conductance
permeability
selectivity
block
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