IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A784

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Adenoviral E1A: everlasting tool, versatile applications, continuous contributions and new hypotheses
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1 Cardeza Foundation for Hematological Research, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
2 Department of Anatomy, Pathology and Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
Academic Editor:Antonio Giordano
Front. Biosci. (Landmark Ed) 2002, 7(4), 407–413; https://doi.org/10.2741/A784
Published: 1 February 2002
(This article belongs to the Special Issue Gene targets for modulating cell growth)
Abstract

Adenoviral E1A is an indispensable protein for virus-host interaction. To provide a suitable environment for viral replication, E1A physically interacts with multiple cellular proteins to reprogram gene expression and other processes of the host cells. Proteins targeted by E1A include the pRb family of pocket proteins, p300/CBP, cyclin/Cdk, the carboxyl terminal binding protein (CtBP), transcriptional regulator YY1, and the recently identified RACK1 and SWI/SNF complex. Reprogramming activity of E1A and the host cell response to this reprogramming lead to transformation, growth arrest or apoptosis. Based on the ability of E1A to override the fundamental controls of host cells, E1A has been being utilized to make continuous contributions not only to a better understanding of the molecular mechanisms underlying the regulation of transcription, cell division, apoptosis and tumorigenesis but also to new therapeutics such as gene therapy.

Keywords
E1A
p300/CBP
pRb
E2F
SWI/SNI
p53
MyoD
HIF-1α
YY1
CtBP
RACK1
apoptosis
transformation
growth suppression
Review
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