IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/welch

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Glomerulonephritis associated with deficiencies and polymorphisms of complement components encoded in the class III region of the MHC

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1 Division of Nephrology and Hypertension, Children's Hospital Research Foundation, Cincinnati, Ohio, USA
2 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio

Academic Editor: C. Yu

Front. Biosci. (Landmark Ed) 2001, 6(3), 898–903;
Published: 1 August 2001

An association between the complement system and immune complex glomerular disease in humans has long been recognized. In fact, much of our early understanding of the immunochemistry of complement activation developed with the study of acute and chronic glomerulonephritis (1). This manuscript will examine associations between glomerulonephritis and the three complement components encoded within the major histocompatibility complex: C4, C2, and factor B (B). The mechanisms by which deficiencies or polymorphisms in these components can mediate disease will be examined.

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