IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/swertfeg

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Apolipoprotein E: a cholesterol transport protein with lipid transport-independent cell signaling properties
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1 Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0529, USA

Academic Editor: David Hui

Front. Biosci. (Landmark Ed) 2001, 6(3), 526–535;
Published: 1 March 2001
(This article belongs to the Special Issue Lipid and lipoprotein metabolism)

Apolipoprotein (apo) E is a 34-kDa glycoprotein associated with plasma lipoproteins. In contrast to other apolipoproteins, apoE is expressed ubiquitously in all tissues and appears to have a wide variety of functions in addition to lipid transport. Although the lipid transport properties of apoE are well characterized, the appreciation apoE functions other than lipid transport is still in an infancy stage. Nevertheless, there is increasing evidence that apoE regulates cell functions in a variety of tissues and organs. This review article summarizes briefly the current status of our understanding on the lipid transport-independent properties of this apolipoprotein.

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