IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/leung

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The structure and functions of human lysophosphatidic acid acyltransferases
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1 Cell Therapeutics, Inc., Seattle, WA 98119, USA

Academic Editor: C. Yu

Front. Biosci. (Landmark Ed) 2001, 6(3), 944–953; https://doi.org/10.2741/leung
Published: 1 August 2001
Abstract

Lysophosphatidic acid (LPA) and phosphatidic acid (PA) are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. LPA acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase (1-AGPAT) (EC 2.3.1.51), catalyzes the conversion of LPA to PA. Two human isoforms of LPAAT, designated as LPAAT-α (AGPAT1) and LPAAT-β (AGPAT2), have been extensively characterized. These two proteins contain extensive sequence similarities to microbial, plant and animal LPAAT sequences. LPAAT-α mRNA is uniformly expressed throughout most tissues with the highest level found in skeletal muscle; whereas LPAAT-β is differentially expressed, with the highest level found in heart and liver, and negligible level in brain and placenta. The LPAAT-α gene is located on chromosome 6p21.3, an area within the class III region of the major hiscompatibility complex (MHC) and the LPAAT-β gene is mapped to chromosome 9q34.3. Enhanced transcription of LPAAT-β is suggested for neoplasm of the female genital tract. Additionally, ectopic LPAAT expression in certain cytokine-responsive cell lines can effect amplification of cellular signaling processes, such as those leading to enhancement of synthesis of tumor necrosis factor-alpha and interleukin-6 from cells following stimulation with interleukin-1β; this suggests that the LPAAT genes represent candidates for affecting the development of certain cancers or inflammation-associated diseases.

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