Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Martin Merkel 21 Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, USA
2 University Hospital Eppendorf, Department of Internal Medicine, Martinistr 52, 20246 Hamburg, Germany
Abstract
Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.