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Article
Lipoprotein lipase: physiology, biochemistry, and molecular biology
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1
Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, USA
2
University Hospital Eppendorf, Department of Internal Medicine, Martinistr 52, 20246 Hamburg, Germany
Front. Biosci. (Landmark Ed) 2001, 6(3), 388–405;
https://doi.org/10.2741/goldberg
Published: 1 March 2001
Abstract
Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.