IMR Press / FBL / Volume 3 / Issue 4 / DOI: 10.2741/A240

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Control of vascular smooth muscle and endothelial cell proliferation and its implication in cardiovascular disease
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1 Department of Medicine (Cardiology) and Department of Biomedical Research, St. Elizabeth's Medical Center, Tufts, University School of Medicine, Boston, MA 02135, USA
2 Present address: Dept. of Cardiology, Medizinische Klinik III, University of Tuebingen,Otfried-Mueller-Str.10, 72076 Tuebingen, Germany
3 Instituto de Biomedicina, Consejo Superior de Investigaciones Científicas, 46010-Valencia, Spain
Front. Biosci. (Landmark Ed) 1998, 3(4), 269–287;
Published: 1 March 1998

At homeostasis, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in the arterial wall are fully differentiated and display a very low proliferative index. However, unlike terminally differentiated cells, mature ECs and VSMCs maintain their ability to dedifferentiate and reenter the cell cycle in response to several environmental stimuli. Because of the contribution of EC and VSMC proliferation to the pathogenesis of several diseases, including cancer and cardiovascular disease, considerable effort has been devoted to elucidate the mechanisms that regulate cell cycle progression in these cell types. These regulatory networks and the implications they may have for cardiovascular disease are reviewed here.

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