- Academic Editor
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Background: A previously unstudied medicinal plant,
Leucophyllum frutescens (Berland.) I.M. Johnst. (Scrophulariaceae) was
investigated to evaluate its potential in preventing and treating
neurodegenerative diseases, including Alzheimer’s disease. Methods:
Methanolic leaf extract (MELE) and its fractions (HELE, CHLE, and BULE) were
evaluated for their polyphenolic content and antioxidant activity by five
different methods, including in vitro enzyme inhibition assays, which
are clinically linked to neurodegenerative diseases. The potentially active
n-butanol fraction (BULE) was further evaluated for its neuroprotective
effects using an albino rat animal model and phytoconstituents profiling using
Liquid chromatography with tandem mass spectrometry (LC–MS/MS), and in silico molecular docking by Maestro®
Schrödinger. Results: The n-butanol fraction (BULE) in the
hydroalcoholic leaf extract exhibited the highest total phenolic content (230.435