IMR Press / FBL / Volume 28 / Issue 5 / DOI: 10.31083/j.fbl2805097
Open Access Original Research
Anti-Diabetic Drugs Inhibit Bulimia Induced Obesity
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1 Department of Cardiology, Affiliated Drum Tower Hospital, Medical School, Nanjing University, 210008 Nanjing, Jiangsu, China
2 Department of Medical Laboratory, Affiliated Drum Tower Hospital, Medical School, Nanjing University, 210008 Nanjing, Jiangsu, China
3 Department of Medical Imaging, Affiliated Drum Tower Hospital, Medical School, Nanjing University, 210008 Nanjing, Jiangsu, China
*Correspondence: (Lina Kang); (Biao Xu)
These authors contributed equally.
Front. Biosci. (Landmark Ed) 2023, 28(5), 97;
Submitted: 5 June 2022 | Revised: 5 January 2023 | Accepted: 9 January 2023 | Published: 22 May 2023
(This article belongs to the Special Issue An Update on Sodium Glucose Co-Transporters)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Obesity is primarily a consequence of food addiction. Drugs have been confirmed effective for weight loss more or less related to the functional connectivity in neural networks and metabolic patterns. Recent studies have shown that some anti-diabetic drugs, such as Metformin and Dapagliflozin have similar weight loss effects, however, their mechanisms are unclear. We hypothesized that the functional connectivity and energy metabolism might be associated with the mechanisms. Methods: Male ob/ob mice were fed with high-fructose-fat-diet (HFFD) for 4 weeks to esteblish obesity model. Then mice were divided into normal saline (NS, as control), Metformin (Metformin, 50 mg/kg/day by gavage), and Dapagliflozin (Dapagliflozin, 10 mg/kg/day by gavage) groups. Functional connectivity amplitude of low-frequency signal fluctuations and regional cerebral blood volume (rCBV) quantification were statistically analyzed in the linear mixed model, meanwhile, metabolic pattern of intestinal cells (IECs) were also tested. Results: Our results showed that Blood Oxygen on Level Depending (Bold) signaling responses, functional connectivity, and rCBV quantification tended to be attenuated in the Metformin group compared to the control and Dapagliflozin groups. While only Dapagliflozin prevented HFFD induced hyper survival of intestinal cells and hypertrophy of intestinal villus by reducing glycolysis levels. Both Metformin and Dapagliflozin are effective for weight loss. Conclusions: Our findings showed that Dapagliflozin and Metformin may inhibit bulimia induced obesity with different mechanisms. We speculate that Metformin may affect appetite regulation, while Dapagliflozin can affect the survival and metabolic patterns of intestinal cells, thus significantly affecting the absorption of nutrients. So, combining Metformin and Dapgliflozin may be more beneficial for clinical improvement in bulimia induced obesity.

neural networks
metabolic patterns
intestinal villus
82070366/Natural Science Foundation of China
ZKX20018/Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health
Fig. 1.
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