IMR Press / FBL / Volume 28 / Issue 2 / DOI: 10.31083/j.fbl2802038
Open Access Review
Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure
Yan Huang1,†Xing Zhang1,2,†Ling Chen3,†Bo Xu Ren1,*Feng Ru Tang4,*
Show Less
1 Department of Medical Imaging, Medical School of Yangtze University, 434023 Jingzhou, Hubei, China
2 Medical Imaging Department, Wuhan Hospital of Traditional Chinese and Western Medicine, 430022 Wuhan, Hubei, China
3 Department of General Practice, Wuhan Fourth Hospital, 430033 Wuhan, Hubei, China
4 Radiation Physiology Lab, Singapore Nuclear Research and Safety Initiative, National University of Singapore, 138602 Singapore, Singapore
*Correspondence: (Bo Xu Ren); (Feng Ru Tang)
These authors contributed equally.
Front. Biosci. (Landmark Ed) 2023, 28(2), 38;
Submitted: 27 December 2022 | Revised: 7 February 2023 | Accepted: 10 February 2023 | Published: 24 February 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Ischemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. Lycium barbarum has anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties, may produce both neuroprotective and radioprotective effects. In this narrative review paper, we described the neuroprotective effect of Lycium barbarum in different animal models of experimental ischemic stroke and limited studies in irradiated animal models. Relevant molecular mechanisms are also summarized. It has been shown that in experimental ischemic stroke models, Lycium barbarum produces neuroprotective effects by modulating neuroinflammatory factors such as cytokines and chemokines, reactive oxygen species, and neurotransmitter and receptor systems. In irradiation animal models, Lycium barbarum prevents radiation-induced loss of hippocampal interneurons. Given its minimal side-effects, these preclinical studies suggest that Lycium barbarum may be a promising radio-neuro-protective drug that can be used as an adjunct treatment to radiotherapy for brain tumor and in the treatment of ischemic stroke. At molecular levels, Lycium barbarum may regulate PI3K/Akt/GSK-3β, PI3K/Akt/mTOR, PKCε/Nrf2/HO-1, keap1-Nrf2/HO-1, and NR2A and NR2B receptor- related signal transduction pathways to produce neuroprotective effects.

ischemic stroke
oxidative stress
Lycium barbarum
molecular mechanisms
Lycium barbarum polysaccharides
Graphical Abstract
View Full Image
81772223/National Natural Science Foundation of China
National Research Foundation of Singapore to Singapore Nuclear Research and Safety Initiative (FRT)
Fig. 1.
Back to top