- Academic Editors
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†These authors contributed equally.
Background: Six transmembrane epithelial antigen 1
(STEAP1) is aberrantly expressed in cancers and could therefore be a potential
biomarker. This study examined the connection between STEAP1 expression and
clinical features/prognosis in cancer patients. Methods: Several
databases were comprehensively searched for related published studies. The
combination of hazard ratios (HRs), odd ratios (ORs), and 95% confidence
intervals (95% CIs) was used to assess the role of STEAP1. The Cancer Genome
Atlas (TCGA) dataset was used to estimate the prognostic value of STEAP1 in
multiple cancer types, and several biological behaviors related to STEAP1 were
evaluated by CancerSEA. Results: Searches of electronic databases
revealed 7 relevant trials with 765 patients. A significant connection was found
between high STEAP1 expression and worse overall survival amongst cancer patients
(HR = 1.87, 95% CI: 1.49–2.34, p