Academic Editors: Shikun He and Graham Pawelec
Purpose: To compare the progression of neovascular remodeling and
subretinal fibrosis in neovascular age-related macular degeneration (NVAMD) after
anti-vascular endothelial growth factor (VEGF) therapy. Methods: Twenty
eyes from 20 patients with subretinal fibrosis complicating NVAMD were
retrospectively reviewed. All patients complied with at least three consecutive
monthly intravitreal treatments and final follow-up visit at 12 months after the
initial anti-VEGF treatment of aflibercept or ranibizumab. Using optical
coherence tomography angiography (OCTA), the central macular thickness (CMT),
microvascular density in the superficial capillary plexus (SCP), deep capillary
plexus (DCP), choroidal neovascularization (CNV) lesions, as well as subretinal
fibrotic lesions were compared between baseline and final visit.
Results: The mean number for anti-VEGF injections was 4.40