IMR Press / FBL / Volume 27 / Issue 2 / DOI: 10.31083/j.fbl2702051
Open Access Review
Circadian rhythms in thrombosis and atherothrombotic events
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1 Cardiology Department, Hospital Universitario 12 de Octubre, and Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain
2 CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain
3 Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain
4 Department of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
5 Department of Preventive Medicine. Hospital Universitario 12 de Octubre and Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain
6 Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain
*Correspondence: hector.bueno@cnic.es (Héctor Bueno)
Academic Editor: Graham Pawelec
Front. Biosci. (Landmark Ed) 2022, 27(2), 51; https://doi.org/10.31083/j.fbl2702051
Submitted: 16 December 2021 | Revised: 11 January 2022 | Accepted: 12 January 2022 | Published: 11 February 2022
(This article belongs to the Special Issue Circadian Rhythms in Health and Disease)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Biological circadian rhythms in living organisms are regulated by molecular clocks. Several of these clocks are present in blood vessels, peripheral tissues, and immune cells. There is strong evidence linking dysregulation of circadian rhythms to the development of cardiovascular disease. Dysregulation of circadian rhythms is believed to activate inflammatory processes at specific times of day, leading to an increased risk of thrombosis and atherosclerosis progression. Research into circadian clock genes and molecular networks has the potential to identify therapeutic targets to reduce cardiovascular risk. In this review, we summarize the evidence linking circadian rhythms to thrombosis and atherothrombotic events and discuss potential therapeutic implications.

Keywords
circadian clock
autonomous
shift workers
thrombosis
atherosclerosis
acute coronary syndrome
stroke
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