IMR Press / FBL / Volume 27 / Issue 10 / DOI: 10.31083/j.fbl2710294
Open Access Review
Perspectives on the Use of Toxicogenomics to Assess Environmental Risk
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1 Instituto de Diagnóstico Ambiental y Estudios del Agua (IDAEA-CSIC), E-08034 Barcelona, Spain
*Correspondence: (José Portugal)
Academic Editor: Guohui Sun
Front. Biosci. (Landmark Ed) 2022, 27(10), 294;
Submitted: 28 June 2022 | Revised: 27 September 2022 | Accepted: 28 September 2022 | Published: 28 October 2022
(This article belongs to the Special Issue Recent Advances in Cancer Research and Environmental Toxicology)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Environmental toxicogenomics aims to collect, analyze and interpret data on changes in gene expression and protein activity resulting from exposure to toxic substances using high-performance omics technologies. Molecular profiling methods such as genomics, transcriptomics, proteomics, metabolomics, and bioinformatics techniques, permit the simultaneous analysis of a multitude of gene variants in an organism exposed to toxic agents to search for genes prone to damage, detect patterns and mechanisms of toxicity, and identify specific gene expression profiles that can provide biomarkers of exposure and risk. Compared to previous approaches to measuring molecular changes caused by toxicants, toxicogenomic technologies can improve environmental risk assessment while reducing animal studies. We discuss the prospects and limitations of converting omic datasets into valuable information, focusing on assessing the risks of mixed toxic substances to the environment and human health.

adverse outcome pathways
risk assessment
molecular toxicology
RTI2018- 096175-B-I00/Spanish Ministry of Science, Innovation, and University
2017SGR902/Generalitat de Catalunya
Fig. 1.
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