IMR Press / FBL / Volume 26 / Issue 4 / DOI: 10.2741/4910

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Association between nitrated lipoproteins and vascular function in type 2 diabetes
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1 State University of New York, Downstate Medical Center, Department of Medicine, 450 Clarkson Ave., Brooklyn, New York 11203, USA
2 SUNY Downstate Health Sciences University, School of Public Health, Department of Epidemiology and Biostatistics, 450 Clarkson Ave., Brooklyn, New York 11203, USA
3 King Abdullah International Medical Research Center (KAIMRC), and King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs, Al Ahsa 31982, Saudi Arabia
Front. Biosci. (Landmark Ed) 2021, 26(4), 644–663; https://doi.org/10.2741/4910
Published: 1 October 2020
Abstract

Higher levels of nitrated lipoproteins (NT-HDL and NT-LDL) were found in blood and atherosclerotic plaques of patients with coronary artery disease. We aimed to examine the relationship between plasma NT-HDL and NT-LDL and diabetic vascular dysfunction. The study included 125 African-American patients with T2DM. NT-HDL and NT-LDL were quantified by ELISA. Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. In univariate analysis, NT-HDL was associated with VRI in total population and in patients with HbA1c ≤7.0% (β= -0.178, p= 0.034; β= -0.265, p= 0.042; respectively). In contrast, NT-LDL was associated with CIMT in total population and in patients with HbA1c >7.0% (β= -0.205, p= 0.022; β= -0.244, p= 0.042; respectively). Multivariable-adjusted regression analysis demonstrated that NT-HDL independently predicted VRI outcome in total population and in well-controlled patients (β= -0.282, p= 0.014; β= -0.400, p= 0.035, respectively). These results suggest that NT-HDL could be used as marker to identify diabetic patients at risk of developing early microvascular complications.

Keywords
African-Americans
Biomarkers
Cardiovascular disease
Endothelium function
Lipoproteins
Myeloperoxidase
Nitration
Nitric oxide
Vascular complications
Type 2 diabetes
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