IMR Press / FBL / Volume 26 / Issue 4 / DOI: 10.2741/4909

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Lamiaceae in the treatment of cardiovascular diseases
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1 Department of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, Campus of Food Science, Piazza Goidanich 60, 47521 Cesena, Italy
2 Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
3 University of Belgrade, Institute of Chemistry Technology and Metallurgy, Njegoševa 12, 11 000 Belgrade, Serbia
4 University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Takovska 43, 11 000 Belgrade, Serbia
Send correspondence to: Danka Bukvicki, University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, 11 000 Belgrade, Serbia, Tel: 381-63-161-1980, Fax: 38-111-324-3603, E-mail:
Front. Biosci. (Landmark Ed) 2021, 26(4), 612–643;
Published: 1 October 2020
(This article belongs to the Special Issue Targeting inflammatory pathways in prevention and treatment of cancer)

Lamiaceae (Labiatae) are an important group of medicinal plants, which have been used for treating heart disease in traditional medicine for centuries. These mainly aromatic plants are used as essential oils, extracts or isolated components (polyphenols, phenolic compounds, terpenes, iridoids etc.). Some Labiatae species (more than 30, such as cornmint, lavender, patchouli, rosemary etc.) are famous for their use in essential oil production worldwide. In this review, cardioprotective effects of Lamiaceae and their active secondary metabolites, as well as mechanism of action against cardiovascular diseases (hypertension, angina pectoris, hyperlipidemia, thromboembolism, coronary heart disease, heart failure, venous insufficiency, arrhythmia) will be discussed. Use of Labiatae as food or food additives (such as spices) may prevent risk of cardiovascular diseases, diabetes and cancer. This approach is also described as a part of the article. Studies on developing new, effective and safe natural products from Lamiaceae (rich source of flavonoids and other active compounds) are promising and may offer prevention and treatment for patients with coronary disease and other related diseases.

Cardiovascular diseases
Lamiaceae family
Active compounds
Figure 1
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