Artificial intelligence (AI) is an iterative process by which information is captured, transformed into knowledge and processed to produce adaptive changes in the environment. AI is a broad concept, involving virtual (computing) and physical (robotics) elements. In this narrative literature review, we focus on the aspects of AI that present major opportunities for developing health care. Within a few years, AI will be part of our daily clinical practice. Although significant advances are being made, the application of AI in musculoskeletal medicine is still in its early stages compared with its implementation in other areas of medicine. AI is increasingly being employed in fields such as musculoskeletal radiology, skeletal trauma, orthopedic surgery, physical and rehabilitation medicine and sports medicine, as well as for “big data” and AI in gastrointestinal (GI) endoscopy related injuries. Among the limitations of IA are that it analyzes information based on the data it is supplied, which must therefore be well-labeled and that some algorithms such as DL uses more time, data, and computational power than other techniques. Moreover, AI currently does not solve the problem of causality that exists in medicine with observational data; information that physicians interpret within a broad clinical context. AI should therefore be integrated in a prudent and reasonable manner into the workflows of health professionals.