Introduction: The restriction of prolyl-protein cis/trans isomerase 1
(Pin1) activity has been shown to prevent the release of tissue factor (TF)
leading to the accumulation of the latter protein within the cell. This study
tested the ability of novel small molecules to inhibit Pin1, suppress TF activity
and release, and induce cellular apoptosis. Methods: Four compounds were
designed and synthesised based on modification of
5-(p-methoxyphenyl)-2-methylfuran-3-carbonyl amide and the outcome on
MDA-MB-231 and primary cells examined. These compounds contained
3-(2-naphthyl)-
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Open Access
Original Research
Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells
Oluremi I Adeniran1, Mohammad A Mohammad2, Sophie Featherby2, Anthony Maraveyas3, Andrew N Boa1, Camille Ettelaie2,*
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1
Department of Chemistry, University of Hull, HU6 7RX Hull, UK
2
Biomedical Section, University of Hull, HU6 7RX Hull, UK
3
Division of Cancer-Hull York Medical School, University of Hull, HU6 7RX Hull, UK
*Correspondence: C.Ettelaie@hull.ac.uk (Camille Ettelaie)
Front. Biosci. (Landmark Ed) 2021, 26(10), 752–764;
https://doi.org/10.52586/4985
Submitted: 22 July 2021 | Revised: 22 September 2021 | Accepted: 23 September 2021 | Published: 30 October 2021
(This article belongs to the Special Issue New Insight into Extracellular Vesicles in Human Diseases)
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Tissue factor
Pin1
Cancer cell
p53
Bax
Synthetic inhibitor
Figures
Fig. 1.