IMR Press / FBL / Volume 25 / Issue 4 / DOI: 10.2741/4833

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Proteoglycan desulfation: a critical step in oncogenesis?
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1 Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
Front. Biosci. (Landmark Ed) 2020, 25(4), 760–780; https://doi.org/10.2741/4833
Published: 1 January 2020
(This article belongs to the Special Issue Elucidation of exosomes role in metastasis)
Abstract

Proteoglycans are essential constituents of tissue- and organ microenvironments, modulating both the structural scaffolds that surround cells as well as signaling cues that determine cellular phenotype. An important modification of proteoglycans is the sulfation of the monosaccharides that comprise them. Sulfates are added by sulfotransferases and desulfation occurs through the action of sulfatases. In this essay, we examine the biochemistry of a conserved family of desulfating enzymes known as arylsulfatases. A subset of these enzymes mediates the desulfation of proteoglycans. We review the consequences of their aberrant expression in the light of carcinogenesis and carcinomatosis: the dissemination of cancer cells. A closer understanding of their cellular-molecular roles reveals their promise for future strategies for cancer therapy.

Keywords
Proteoglycans
Arylsulfatase
Cancer
Epithelial To Mesenchymal Transition
Review
Figures
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