IMR Press / FBL / Volume 25 / Issue 10 / DOI: 10.2741/4880

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Soluble (pro)renin receptor in elderly chronic heart failure patients
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1 Department of Cardiology-Internal Medicine, Heart Center Leipzig, University Leipzig, Leipzig 04289
2 Institute for Cardiovascular Diseases “Dedinje”, University of Belgrade, Belgrade 11040
3 Department of Cardiology Campus Virchow, Charite Universitatsmedizin Berlin, Berlin 13353
4 CellTrend GmbH, Im Biotechnologiepark, Luckenwalde 14943
5 Department of Urology, Charite Universitatsmedizin Berlin, Berlin 10117
6 Experimental and Clinical Research Center, Max Delbruck Center for Molecular Medicine, Berlin 13125
7 Berlin Institute of Health (BIH), Berlin 10178
8 HealthTwiSt GmbH, Berlin, German 13125
9 Department of Cardiology, University Clinical Hospital “Bezanijska Kosa”, University of Belgrade, Belgrade 11000
10 Saxon Incubator for Clinical Translation, University Leipzig, Leipzig 04103
Front. Biosci. (Landmark Ed) 2020, 25(10), 1839–1853; https://doi.org/10.2741/4880
Published: 1 June 2020
Abstract

Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue RAS), which mediates tissue injury through fibrosis and hypertrophy of the affected organs in CHF patients. In our study we used plasma samples from 556 elderly subjects with CHF and 198 healthy participants in order to evaluate prognostic and diagnostic potential of s(P)RR in setting of CHF. The patients with CHF showed significantly higher plasma levels of s(P)RR than the healthy volunteers (p=0.0005). We observed association between higher s(P)RR plasma concentrations and lower left ventricular ejection fraction and higher degree of left ventricular dilatation on baseline echocardiography examination of the CHF patients. Elderly CHF patients with higher baseline s(P)RR plasma concentration were at same risk for death, stroke and hospitalization due to heart failure worsening at mean follow-up from forty-eight months in comparison to low s(P)RR counterparts.

Keywords
chronic heart failure
soluble (pro)renin receptor
left ventricular ejection fraction
left ventricular remodeling
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