Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Intestinal enteroendocrine L cells in amino acid sensing and diseases
, Chien-An Andy Hu 1,2,3, Pengfei Huang 1, Yali Li 1, Shanping He 1, Huansheng Yang 1, Jianzhong Li 1, Huaping Xie 1, Yulong Yin 1,21 Laboratory of Animal Nutrition and Human Health, School of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, China
2 Human Engineering and Research Center of Animal and Poultry Science, Key Lab Agroecology Processing Subtropical Region, Scientific Observational and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan, 410125, China
3 Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM, USA 87131, Mexico
Abstract
Enteroendocrine L cells are open-type enteroendocrine cells that play an important role in amino acid sensing. They detect amino acids by a number of membrane receptors such as calcium-sensing receptor and G protein coupled receptor family C group 6 subtype A. The receptors activate signaling pathways and trigger cellular electrical activities, inducing gut hormones secretion (glucagon-like peptide 1, glucagon-like peptide 2 and peptide YY). This review focuses on an array of findings on L cells as models, receptors and signaling pathways, electrical activities and hormones secretion in amino acid sensing. Several diseases that are closely related to L cells are also reviewed.
Keywords
- Amino acid sensing
- Disease
- Electrical activity
- Hormone secretion
- Intestinal enteroendocrine cells
- L cells
- Review