IMR Press / FBL / Volume 23 / Issue 7 / DOI: 10.2741/4641

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization

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1 School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian China
2 Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
Front. Biosci. (Landmark Ed) 2018, 23(7), 1241–1256;
Published: 1 January 2018
(This article belongs to the Special Issue Membrane transport)

Store-operated calcium entry (SOCE) is the predominant calcium entry mechanism in most cancer cells. SOCE is mediated by the endoplasmic reticulum calcium sensor STIMs (STIM1 and 2) and plasma membrane channel forming unit Orais (Orai 1-3). In recent years there is increasing evidence indicating that SOCE in cancer cells is dysregulated to promote cancer cell migration, invasion and metastasis. The overexpression of STIM and Orai proteins has been reported to correlate with the metastatic progression of various cancers. The hyperactive SOCE may promote metastatic dissemination and colonization by reorganizing the actin cytoskeleton, degrading the extracellular matrix and remodeling the tumor microenvironment. Here we discuss how these recent progresses provide novel insights to our understanding of tumor metastasis.

Store-operated Calcium Entry
Calcium signaling
Cancer metastasis
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