IMR Press / FBL / Volume 23 / Issue 6 / DOI: 10.2741/4632

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Nanoparticles in wound healing; from hope to promise, from promise to routine

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1 Division of Surgery and Interventional Science, University College London, London, UK
2 Reconstructive Surgery and Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK
3 School of Medicine, Imperial College London, London, UK
4 The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
5 Department of Plastic Surgery, Royal Free NHS Foundation Trust, London, UK
6 Nanotechnology & Regenerative Medicine (Ltd) Commercialisation Centre, The London BioScience Innovation Centre, London, UK
Front. Biosci. (Landmark Ed) 2018, 23(6), 1038–1059; https://doi.org/10.2741/4632
Published: 1 January 2018
(This article belongs to the Special Issue Nanoparticles in wound healing)
Abstract

Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical and biological properties unique from their bulk equivalent. These nanoparticles can be incorporated into scaffolds to create nanocomposite smart materials, which promote wound healing through their antimicrobial, as well as selective anti- and pro-inflammatory, and pro-angiogenic properties. Owed to their high surface area, nanoparticles have also been used for drug delivery as well as gene delivery vectors. In addition, nanoparticles affect wound healing by influencing collagen deposition and realignment and provide approaches for skin regeneration and wound healing.

Keywords
Nanoparticle
Wound Healing
Silver Nanoparticles
Tissue Regeneration
Review
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