IMR Press / FBL / Volume 23 / Issue 11 / DOI: 10.2741/4698

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Antibodies against GPCR

Show Less
1 CellTrend GmbH, Luckenwalde, Germany
Front. Biosci. (Landmark Ed) 2018, 23(11), 2177–2194; https://doi.org/10.2741/4698
Published: 1 June 2018
Abstract

G-protein-coupled receptors (GPCRs) are the largest family of receptors in humans. GPCRs are seven-transmembrane receptors that are activated by the binding of a ligand to the extracellular domain. In addition to the endogenous ligands, auto-antibodies (aab) can also bind to the GPCRs. They can activate different and specific cellular pathways which contribute to various diseases. In this review, the authors summarize the knowledge about antibodies targeting GPCRs and their effects and relevance in the pathogenesis of various diseases and their use in clinical diagnostics. We highlight the role of different activating anti-GPCR aab in solid organ transplantations, stem cell transplantations, systemic sclerosis, preeclampsia, chronic fatigue syndrome, cardiovascular diseases, Alzheimer’s disease, and cancer.

Keywords
GPCR
anti-GPCR antibody
AT1R antibody
non-HLA antibody
beta adrenergic receptor antibody
Review
Share
Back to top