IMR Press / FBL / Volume 23 / Issue 11 / DOI: 10.2741/4691

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Role of alpha1-adrenergic receptor antibodies in Alzheimer’s disease

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1 E.R.D.E.-AAK-Diagnostik GmbH, Berlin, Germany
Front. Biosci. (Landmark Ed) 2018, 23(11), 2082–2089; https://doi.org/10.2741/4691
Published: 1 June 2018
Abstract

Agonistic autoantibodies (agAAB) for alpha-1 adrenoceptor were found in approx. 50% of patients with Alzheimer’s disease. These antibodies activate the receptor and trigger the signal cascades similarly to how natural agonists do. The agAAB bond to the receptor is persistent and prolonged. This results in a non-physiological elevation of intracellular calcium. An animal model has shown that agAAB causes macrovascular and microvascular impairment in the vessels of the brain. Reduction in blood flow and the density of intact vessels was significantly demonstrated. The agAAB was removed through immunoadsorption in a small cohort of patients with Alzheimer’s disease. Subsequent follow-up observations over 12-18 months noted stabilization of cognition levels.

Keywords
Dementia
Agonistic Autoantibodies
Immunoadsorption
Review
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