IMR Press / FBL / Volume 22 / Issue 4 / DOI: 10.2741/4501

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Expression of proteins in intestinal middle villus epithelial cells of weaning piglets

Show Less
1 Chinese Academy of Science, Institute of Subtropical Agriculture, Research Center for Healthy Breeding Livestock and Poultry, Hunan Engineering and Research Center for Animal and Poultry Science, Key Laboratory of Agroecology in Subtropical Region, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Changsha 410125, Hunan, China
2 University of Chinese Academy of Sciences, Beijing 100039, China
3 School of Life Sciences, Hunan Normal University, Changsha, China
4 Fujian Aonong Biotechnology Corporation, Xiamen, Fujian, China
5 Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, Hunan Collaborative Innovation Center of Animal Production Safety, Changsha 410128, China
6 Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China
7 Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
Academic Editor:Guoyao Wu
Front. Biosci. (Landmark Ed) 2017, 22(4), 539–557; https://doi.org/10.2741/4501
Published: 1 January 2017
(This article belongs to the Special Issue Amino acids in nutrition, health, and disease)
Abstract

Weaning affects intestinal development in mammals, and pigs are often used as an animal model for analyzing the metabolism and physiology of differentiating middle villus intestinal epithelial cells (DIECs). To assess the impact of weaning on the proteomes of DIECs, we weaned piglets on day 14 and collected their jejunum on days 0, 1, 3, 5, and 7 after weaning. Levels of proteins associated with (a) Golgi vesicle transport and protein glycosylation; (b) monosaccharide, lipid, phospholipid, and nucleotide metabolism; and (c) Krebs cycle and respiratory electron transport chain were decreased in DIECs after weaning. These results indicate that weaning decreases nutrient metabolism in DIECs. Moreover, these results suggest that dietary interventions (e.g.,supplementation with functional amino acids) are required to counter these changes.

Keywords
Weaning
Middle Villi
Epithelial Cells
Piglet
Jejunum
Review
Share
Back to top