IMR Press / FBL / Volume 22 / Issue 10 / DOI: 10.2741/4560

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Pathogen-associated regulatory non-coding RNAs and oncogenesis

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1 Laboratory of Microbiology and Cell Biology, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan

Academic Editor: Tominori Kimura

Front. Biosci. (Landmark Ed) 2017, 22(10), 1599–1621; https://doi.org/10.2741/4560
Published: 1 March 2017
(This article belongs to the Special Issue Regulatory long non-coding RNA)
Abstract

Among all new cancer cases in 2012, on average, 15.4% were caused by Helicobacter pylori or oncoviruses, including Epstein-Barr virus, human papillomavirus, hepatitis B virus, hepatitis C viruses, Kaposi sarcoma-associated herpesvirus and human T-lymphotropic virus. These pathogens encode a variety of non-coding RNAs, which are important cofactors for oncogenesis. In this review, we focus on recent developments in the study of long and small non-protein-coding RNAs, including microRNAs, of oncogenic pathogens, and discuss their mechanisms of action in the multiple steps of oncogenesis.

Keywords
Regulatory non-coding RNA
Oncogenesis
microRNA
Small ncRNA
Long ncRNA
Cancer hallmarks
Review
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