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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Jan 2017Review

MALAT1-mediated tumorigenesis

Jianghua Liu 1, Wan-Xin Peng 2,3, Yin-Yuan Mo 4, Dianzhong Luo 5,*
Affiliations
Article Info

1 Department of Emergency Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

2 Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

3 Department of Cell Biology, School of Medicine, Jiangsu University, Zhenjiang, China

4 Department of Pharmacology and Toxicology, Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

5 Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

Abstract

Functional genomics studies over the past decades have unveiled that the human genome transcribes a large amount of long noncoding RNAs (lncRNAs) which have been implicated in regulation of diverse cellular functions. Dysregulation of lncRNAs are often associated with human diseases including cancer. The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is among the most abundant and highly conserved lncRNAs. Emerging evidence has indicated that MALAT1 may have complex and extensive functions in the development and progression of cancer. In this review, we first update on the role of MALAT1 in tumorigenesis and then discuss possible molecular mechanisms that underline the MALAT1-mediated gene regulation, leading to cancer invasion and metastasis.

Keywords

  • MALAT1
  • lncRNA
  • Tumorigenesis
  • Cancer
  • Epigenetic Regulation
  • Review

References