IMR Press / FBL / Volume 21 / Issue 6 / DOI: 10.2741/4445

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Transcription factors in the development of inner ear hair cells

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1 Department of Otolaryngology and Head-Neck Surgery, Zhenjiang First People’s Hospital, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2016, 21(6), 1118–1125;
Published: 1 June 2016
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)

Inner ear hair cells are the sensory receptors that detect and convert sound vibrations and head movements into neural signals. However, in humans, these cells are unable to regenerate if they are damaged or lost. Over thepast decade,there has been an exponential increase in interest and progress in understanding of the development of the inner ear and of hair cells, aiming to gain insights into hair cell repair or even regeneration. In hair cell development, various transcription factors have been found to be involved in the processes of hair cell proliferation, differentiation and survival. Among these transcription factors, Math1, Gata3, Sox2 and Atoh1 have been highlighted for their crucial role in the fate of hair cells. In this article, we will summarize the current understanding of the role of transcription factors in hair cell development, focusing on the role and possible mechanisms of Math1, Gata3, Sox2 and Atoh1.

Inner Ear
Hair Cell
Transcription Factor
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