IMR Press / FBL / Volume 21 / Issue 4 / DOI: 10.2741/4422

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Lipid rafts, ceramide and molecular transcytosis

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1 Department of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China
2 Department of Pharmacy, Hubei University of Arts and Science Affiliated Xiangyang Central Hospital, Xiangyang, 441000, Hubei, China
3 Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
4 Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology. The Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation of Hubei Province. Wuhan, 430030, China
Academic Editor:Pin-Lan Li
Front. Biosci. (Landmark Ed) 2016, 21(4), 806–838; https://doi.org/10.2741/4422
Published: 1 January 2016
(This article belongs to the Special Issue Molecular pathobiology of lipid mediators)
Abstract

Transcytosis, a widely described process concerning transport of macromolecules between the apical and basolateral sides in various cell types, is extremely important for multicellular organisms to selectively exchange materials in different microenvironments while maintaining cellular and body homeostasis. Uncontrolled transcytosis is involved in a wide range of pathophysiological processes. Lipid rafts (LRs), the sphingolipid and cholesterol-enriched membrane microdomains, enable to form different functional membrane macrodomains or platforms upon stimulations. In particular, ceramide-enriched membrane microdomains play extremely critical roles in LRs clustering or platform formations. Notably, various transcytosis-related molecules are tightly correlated with LRs and ceramide. We attempt to summarize the basic and advanced information about the roles of different types of transcytosis in human health and diseases, and the types and functions of LRs involved in transcytosis, as well as multiple transcytosis-related molecules associated with LRs and ceramide. It is hoped that all information and discussions could provide much more comprehensive insights into the understanding of the association of LRs with transcytosis, as well as shed some new light on the translational significance in this area.

Keywords
Transcytosis
Lipid Raft
Ceramide
Atherosclerosis
Review
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