IMR Press / FBL / Volume 20 / Issue 4 / DOI: 10.2741/4332

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Differential effects of peripheral and transitional prostatic stromal cells on tumorigenesis
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1 Department of Urology, Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
2 Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2015, 20(4), 716–727; https://doi.org/10.2741/4332
Published: 1 January 2015
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

The human prostate contains two types of stromal cells, peripheral stromal cells (PSCs) and transitional stromal cells (TSCs). Here, we demonstrate the effects of PSCs and TSCs on tumorigenesis in prostate cancer (PCa) and identify the mechanisms underlying these effects. Using microarray analysis, we identified 3,643 differentially expressed genes in cocultures of TSCs, PSCs, and DU145 cells, a human prostate cancer cell line. Expression of cell division cycle 25 homolog A (CDC25A) was lower and that of tumor-associated calcium signal transducer 2 (TACSTD2) was higher in TSCs than in PSCs. Additionally, increased CDC25A expression or decreased TACSTD2 expression modulated the survival, growth, and migration of DU145 cells. These data suggest that PSCs promote and TSCs inhibit tumorigenesis by regulating the expression of CDC25A and TACSTD2.

Keywords
Prostate
Normal
Cancer
Peripheral Zone
PSCs
TSCs
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